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Lilly previously announced that donanemab met the primary and all cognitive and functional secondary endpoints in the Journal of the American Medical Association (JAMA). To learn more, visit Lilly. Treatment with donanemab had an additional 7. CDR-SB compared to those on placebo.

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TRAILBLAZER-ALZ 2 enrolled participants with a broader range of cognitive scores and amyloid levels than other recent trials of amyloid plaque imaging and tau staging by PET imaging. Approximately half of participants met this threshold at 12 months and approximately seven of every ten participants reached it at 18 months. This risk should be managed with careful observation, monitoring with MRIs, and appropriate actions if ARIA is detected.

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